- Title
- Lipid peroxidation and antioxidant defenses in paediatric oncology patients undergoing chemotherapy
- Creator
- Ikeda, E. Beatrix; Collins, Clare E.; Alvaro, Frank; Marshall, Glenn; Garg, Manohar L.
- Relation
- Journal of Cancer Integrative Medicine Vol. 3, Issue 2, p. 41-50
- Publisher
- Society for Integrative Oncology
- Resource Type
- journal article
- Date
- 2005
- Description
- This cross-sectional study describes oxidative stress and antioxidant status in 54 pediatric oncology patients undergoing chemotherapy. Plasma 8-iso-prostaglandin-F2α(8-iso-PGF2α), vitamins A and E and β-carotene, and erythrocyte activities of superoxide dismutase and glutathione peroxidase levels were assessed. One-third of the patients (34%) had plasma 8-iso-PGF2α levels higher than the upper limit of the normal range (> 40 ng/mL). The majority (> 80%) had plasma levels of vitamins A and E and β-carotene within the normal range. Superoxide dismutase activity was lower than the reference range (< 2.4 U/mg Hb) in all patients, whereas erythrocyte glutathione peroxidase activity was lower than the reference range in 46%. Advanced-stage cancer was associated with increased lipid peroxidation but treatment-related factors or use of dietary supplements was not, suggesting that the oxidant-antioxidant balance may be disturbed in a large proportion of this group. Prospective studies would establish whether antioxidant supplementation plays a role in clinical treatment for pediatric oncology patients.
- Subject
- antioxidants; chemotherapy; lipid peroxidation; oxidative stress; paediatric oncology
- Identifier
- http://hdl.handle.net/1959.13/939709
- Identifier
- uon:12863
- Identifier
- ISSN:1544-6301
- Language
- eng
- Reviewed
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